The cees dekker Diaries
The cees dekker Diaries
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Rotary movement of DNA rotors on nanopores. Leading row: raw video clip on the Cy5 channel of each rotor. Middle row: corresponding one-particle localization benefits of each finishes in the DNA rotors. The position of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames before The present frame is demonstrated as solid traces.
Our group scientific studies bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our key fascination lies in cell division, chromatin composition, and spatial control.
[Laughs] ‘It absolutely was certainly an excellent danger! At the time, I had been perfectly knowledgeable that it could go Completely wrong Which I could turn into a lot less effective, but I just ignored that. Curiosity has always been my strongest driving drive. And by chance all of it worked out.’
Our get the job done was promptly adopted up by Many others, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 posted their conclusions on transistors made from single- and multi-walled carbon nanotubes in Applied Physics Letters.
2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and first at any time study of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact these elements alongside one another make up a residing procedure. The key of reported daily life, I do think, lies while in the interactions, the interaction of People molecules. The massive issue about the origin of lifetime is still unanswered. How did we ever evolve from very simple molecules in to the particularly complicated devices we see these days? We do not know. I need to operate on These types of massive, open issues.’
Nanopores represent an elegant and versatile tool to measure cees dekker single molecules. We research novel detection modes with sound-condition nanopores and also a variety of strategies to evaluate proteins with nanopores. Assignments encompass the next:
‘You should not just think of the inquiries of tomorrow, and also evaluate the thoughts of your working day just after tomorrow’
Very amazing, but that wasn’t really the place my desire lay. I desired to pioneer And that i experienced the feeling that was no more possible, because the most appealing fundamental insights had previously been uncovered. But my industry had produced quite a few thrilling new equipment to evaluate person molecules. I made a decision which i needed to apply this to biology, to take a look at it from a Actual physical standpoint.’
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
Nature Physics many thanks the anonymous reviewers for his or her contribution on the peer evaluation of the operate.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond intelligent layout in 2005. (nl)